Does taking amitriptyline 10mg affect Botox?

Checking for drug interactions before starting any new medication or treatment is very important. In particular, Amitriptyline is known to have 267 major and 746 moderate drug interactions. Botox and Amitriptyline do not have any reported interactions. There is a remote possibility of dry mouth, blurred vision, or urinary issues based on the way each medicine works in your body. When injected properly, Botox will only work in the muscles where it is injected. If any new symptoms arise, it's always a good idea to contact your physician.I recommend that you consult with a trained professional for your first Botox injections. They can answer your questions and administer the Botox as safe as possible. 

Thank you for your question.  Amitriptyline will not effect the duration of Botox, however there is a small chance the combo may increase anti-cholinergic like effects, i.e. dry mouth, blurry vision, etc.  For cosmetic dosing of Botox, I would not be concerned.  Regards, Dr. Matt Elias