Preventing capsular contracture with pentoxifylline while under going radiation?

Hi there,
Clearly you are well informed about your reconstruction and ongoing treatment and that is a really good thing.

Unfortunately, not much has conclusively been shown to reduce capsular contraction in the setting of radiation.  The combination of implants and your tissue do not respond well to radiation and often may harden with time.

My best experience has been fat grafting around the implant after radiation and this seems to soften the implant and even reduce pain and early stages of capsule formation.  If you do develop a capsule, changing the implant and removal of the capsule, or replacing the implant with your own tissue may resolve the issue.

Pentoxifylline has been used in a few clinical situations, specifically in peripheral vascular disease to reduce lower limb pain.  It's mechanism of action may be increased blood flow.   The cause of capsular contraction is not clear but increasing blood flow to this area will not necessarily reduce capsular contraction. I have not heard of any evidence to justify its use to reduce capsular or prevent this problem.

The use of Trental to prevent capsular contractures has been shown to be successful in some cases.    Would let your radiation oncologist know that you are interested in any attempts to prevent contractures.  The use of trental is certainly not going to hurt.   Best of luck during your upcoming radiation treatments.