5-FU injections after blepharoplasty to reduce scar tissue?

Question

3 months ago I had a blepharoplasty & have been receiving 5-fu injections to reduce scar tissue every other week. It’s been about 3 weeks since my last 5-fu injection, but still the injection site is surrounded with dry, red, darkened skin. Should this discoloration fade with time? Could the darkness be permanent? I am concerned since it has been 3 weeks since last injection. I am Fitzpatrick skin type 1, if that matters. Thank you so much for your time & consideration.

Ali Cetinkaya, MD · Answer

The redness, dryness, and darkened skin around the injection site after 5-FU treatment post-blepharoplasty is usually temporary. However, since you are Fitzpatrick skin type 1, your skin is quite fair and can be more reactive or sensitive.
5-FU injections can cause local irritation and may lead to temporary hyperpigmentation&mdash;or, less commonly, hypopigmentation. Three weeks post-injection is still within a normal healing window, but this process can sometimes take several weeks or even months.
If the discoloration hasn’t improved or seems to be worsening, I would recommend following up with your surgeon or a dermatologist for evaluation. In the meantime, sun protection is crucial. Use a broad-spectrum sunscreen daily to help prevent the pigmentation from becoming permanent. Your doctor may also suggest topical treatments or lightening creams if needed.

5-FU injections after blepharoplasty to reduce scar tissue?

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