Thank you for your question about neuromodulators (relaxers such as Botox, Dysport, Xeomin and Juveau), fillers and lasers. Kids frown as well as adults. In youth we have a robust amount of collagen, hyaluronic acids and elastin in our skin which work to help it be resilient and flexible. As we age, small wrinkles start to form but are not seen in relaxation and so don’t bug us much. For that matter even deeper lines and grooves don’t bother us that much as long as we don’t see them when our muscles are relaxed. It is when those grooves and lines and creases stare back at us that so many people decide it is time for an intervention.Years ago we only had fillers and so every depression received a filler. Then we got lasers and we were able to treat the color changes of aging skin such as brown spots and redness and we were able to stimulate some collagen which helped to firm up the skin providing for some improvement in fine wrinkles, not folds or grooves. The we got relaxers and started trying to improve every wrinkle with a relaxer. Relaxers are wonderful at decreasing muscle movement. And, if reducing movement could over time help a groove or dynamic wrinkle be less deep, then that was very nice. Now back to your line. Yes, putting some relaxer such as Botox or the others mentioned above, in the muscles that are creating your groove can minimize it’s depth over time. They do not fix anything nor make anything go away for good. They will improve the glabellar line area, need regular upkeep - typically every 3-4 months depending on the dosage of material used and the strength of your muscles and your metabolism. Hyaluronic acid fillers tend to last 9-12 or so months, or maybe much longer, depending on the person and where they are being put. You will want to be treated by someone who knows the anatomy as there are, for example blood vessels and nerves below the bottom of your glabellar line. When I place fillers, I do not put needles down in the bottom of that line. I prefer to make bridges of material across the lines. Long story… See someone who has been doing treatments for a long, long time. As to the CO2 laser. I first started using that laser in 1995. It is likely a great lasers for you skin type (blue eyes…), subject to whatever your actual provider thinks, and can help with fine wrinkles, skin texture, tone… It will, in my experience and thus opinion, not be of help with your glabellar line.In summary, you could certainly consider getting the area relaxed a bit, not paralyzed. You would want to keep some freedom of expression. And I would recommend that a little filler in the area could be very nice, would help further improve the result and it does not usually need to be repeated for a very long time. By the way, your skin has lots of hyaluronic acid in it already. If that is the type filler you doctor might use that will simply be “topping up” what your body can’t keep adequately replaced. I hope that that helps. Best of luck!