The short answer to your question is - Yes. To begin, I think it would be useful to classify the potential complications as either: Medical (allergic reactions, nausea, etc) Surgical (poor scarring, pair, numbness, infection, bleeding etc), or Implant related complications, which can be further classified as either: Those related to stretching of the tissues implant malposition palpability rippling thinning of the overlying breast tissue implant exposure and extrusion, and re-operation Other (implant rupture, capsular contracture, animation) Larger implants will increase your risk of implant complications that are secondary to stretch deformities of the tissues. In my opinion, some element of tissue-based planning should be employed during the sizing process. The measurements taken and observations made during tissue-based planning will help to ensure that you stay within a relatively safe range of implant size that minimizes your risk of complications.