Is there a possibility that the PRP will not be absorbed by the body?

Question

I know someone that had the O-shot and after 8 days developed a round firm ball where the G-spot was injected.

Jennifer Adams, MD · Answer

Hello there,
The O-Shot involves injections of your body's own formed PRP (platelet-rich plasma) with very a minimal side-effect and complication profile. There can be very mild inflammation initially, but developing a firm 'ball' would be highly unusual. I would recommend she see her physician if it does not resolve.Hope that helps!Sincerely,Jennifer Adams, MD, FRCSC

Sue Kafali, MD · Answer

Yes, the PRP is always absorbed by the body, since it is made from your own blood and contains natural growth factors. What can sometimes happen after an injection is that the PRP forms a small pocket or collection under the tissue, which can feel like a firm lump for a short period of time. This is not harmful, and in most cases it softens and is absorbed within a few days to a few weeks as the platelets release their growth factors and the tissue remodels.
If the lump persists beyond a few weeks, or if there is pain, redness, or swelling, it would be important to have it examined to rule out other causes. But generally, a temporary firm spot after the O-Shot is a normal part of the healing process and not a sign that the PRP isn’t being absorbed. Thank you and I hope this helps!

Lori Warren, MD · Answer

Hi! I have never seen anyone reject or capsulize their own PRP. There is an calcium chloride activator added to the O shot and/or some offices add exosomes. I have never seen anyone have that type of reaction to an O shot or the calcium chloride. I would have your friend call the office and be seen for assessment so the provider can look further into this ball. Initially you will have some fluid that may look or feel somewhat engorged at the time of injection, but that should all flatten out within a couple of days at the most, if not way sooner. I hope that helps.

Ebru Unal, MD · Answer

hello if the procedure is done with o shot which is prp , it doesn't leave any mass behind. but because of the application process to the tissue, there may be some bleeding which may be collected underneath the mucosa at the vagina g spot area. this is called hematoma and will be resolved in 3 weeks. best

David Ghozland, MD · Answer

Thanks for your question—and I completely understand the concern.

It’s not common, but occasionally after an O-Shot, patients may notice a small, firm area at the site of the injection, especially in the G-spot region. This is usually due to a localized collection of Platelet-Rich Plasma (PRP) or mild tissue swelling as part of the body’s healing response.

The good news is that this is typically temporary and resolves on its own within a few weeks as the PRP is absorbed and the tissue remodeling process continues.

If the area is:

Painful

Increasing in size

Red or warm to the touch

…then it should be evaluated, as these symptoms may suggest an infection or other rare complication. But in most cases, a firm bump after the O-Shot is benign and self-limiting.

We always encourage patients to reach out if they experience anything unusual so we can guide them properly. Feel free to share this with your friend—and we’re happy to provide a professional opinion if she’d like to be seen.

Warmly,
Dr. David Ghozland

Jennifer R. Berman, MS, MD · Answer

While PRP (Platelet-Rich Plasma) is generally well-absorbed by the body, factors like poor injection technique, underlying health conditions, or improper platelet concentration can impact its effectiveness. PRP works best when injected into healthy tissues with good blood flow, as this supports optimal absorption and healing. Choosing an experienced provider and ensuring FDA-cleared PRP systems are used can maximize results. If you're concerned about absorption or results, consult a specialist to evaluate your situation. I am a doctor and menopause expert. I am considered LA’s Leading Expert in Menopause and Sexual Health

Pranav Shukla, MD · Answer

I think in your case it is most likely swelling secondary to injection. In areas such as the clitoris when you inject PRP, it takes a while for PRP to get absorbed. It will eventually go away. A gentle massage will help to resolve it quickly.

Samer Muala, MD - Account Suspended · Answer

The way PRP works makes it impossible to not be absorbed since it is in effect plasma which the body reabsorbs all the time.  The round firm "ball" could be clotted blood, a reaction to the injection, infection, injury to urethra-  I stronly suggest that she gets reevaluated by her doctor.  Thanks.

Jaime L. Sepulveda, MD - Account Suspended · Answer

The O-Shot is not injected on the G spot. The G-shot which is done with fillers is injected at the G-spot. It may create an elevated area. Platelet Rich Plasma, used in the O-Shot distributes thoughtout the underlayer (fibromuscular plane) of the vaginal tissue, not in a limited segment as it happens in the G-shot.

Is there a possibility that the PRP will not be absorbed by the body?

Answers (9)

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