Can the O shot work for a 75 year old woman?

Yes, the O-Shot is an option at your age, but expectations should be realistic. The response may not be as strong or long-lasting as it is for premenopausal women, but you would still notice improvement and a positive change in sensation and orgasm. PRP is your body’s own natural growth and rejuvenating factor, so it is safe and can definitely help.
For even better results, the O-Shot can be combined with gentle radiofrequency treatments such as Forma-V. This approach rejuvenates the vaginal mucosa—from the cervix to the opening—by stimulating new collagen and improving blood flow. When paired with PRP, the outcome is often smoother tissue, better sensitivity, and longer-lasting improvement.
The O-Shot can give you the change you are looking for, and combining it with treatments like Forma-V can enhance and extend the benefits. Thank you for your question and I hope this helps!

O shot can be done at any age. It is safe as it uses PRP from your own blood. It will help rejuvenate the area and enhance sensation. Results may not be as good as in a younger age but it will definitely help. We also use PRP for postmenopausal women with lichen sclerosis.

Short answer: Probably not your best first step. The “O-shot” (PRP injected near the clitoris/anterior vaginal wall) has very limited, low-quality evidence for orgasm problems at any age. It isn’t FDA-approved for sexual function, results are inconsistent, and benefits—if any—tend to be modest and temporary. Risks are low but include pain, bruising, and infection.
Higher-yield things to try first
Local estrogen (vaginal cream/tablet/ring) or DHEA (prasterone) for dryness/atrophy that can blunt arousal and orgasm.
Pelvic-floor PT (over-tense muscles can block orgasm) and regular use of a strong vibrator/wand to increase arousal.
Medication review: SSRIs and some BP meds can delay orgasm—ask about switches or adding bupropion if appropriate.
Address health factors: diabetes control, neuropathy, cardiovascular fitness, sleep, alcohol.
If low desire is the main issue, discuss low-dose transdermal testosterone (off-label but guideline-supported in postmenopausal women with HSDD), plus sex therapy.
If you still want PRP
Manage expectations; there’s no solid RCT evidence it outperforms placebo.
Avoid if you have a bleeding/platelet disorder or are on strong anticoagulants.
Choose a clinician who uses true PRP (about 3–5× platelet concentration) and explains realistic outcomes and aftercare.
Bottom line: At 75, many women regain satisfying orgasms by treating vulvovaginal atrophy, optimizing stimulation, tuning meds, and working with pelvic-floor and sexual-health specialists. Try these first; consider the O-shot only as an optional, experimental add-on.