Thank you for your question. Please know that it is a common misconception that implant size correlates with the bra cup size. A bra-cup size itself requires many measurements to describe it. Bra sizes vary among manufacturers, and they can label the cup size by any designation they choose. So a C will be a D for another. Additional factors, such as demi and full cup coverage, specific fabrics, padding, and elastics, can all affect the fit of a bra. If we consider all things being equal – i.e., you get a bra from the same manufacturer and of the same style, - then I think you might find it helpful to know that a study by Dr. Bengtson and Dr. Glicksman titled “Standardization of Bra Cup Measurements” has shown that the average implant volume required to increase the cup-size by 1 size is equal to 205 ccs. It was also found that normally breast augmentation increases the cup size by 2. However, it is also important to consider the profile as even a smaller implant with a high profile can increase cup-sizes by the same amount. Now, it may be helpful to do bra-sizing trials with the bra of your choice when you go in for a pre-operative consultation with your board-certified plastic surgeon. Now, although you give importance to cup size designation, what should matter most is that the implant looks good aesthetically and that the chosen bra fits and feels comfortable. The implant has to fit YOUR body dimensions. The more you deviate from the proper fit, the more fake your breasts will look. Surgeons use what is called tissue-based planning. The planning takes into account the effects of implants on tissues over time, risks of excessive stretch, excessive thinning, visible or palpable implant edges, visible traction rippling, ptosis (Sagging), and breast tissue wasting. To determine the final implant size, breast measurements need to be made: base-width, breast skin stretch and nipple-to-Inframammary fold distance. The combination of these measurements will help determine tissue coverage and the required implant volume to optimally fill the breasts. If the skin covering your breasts is stretchy (>2 cm), or if your nipple-to-inframammary fold distance is greater than 9.5 cm, then more volume is needed for the optimal fill. So please focus more on having full and natural looking breasts rather than trying to fit into a particular bra-cup size. That being said, a 45 cc difference in implant size does not make a noticeable difference. At least over 50-100 cc is needed to allow a noticeable difference.If 450 cc is slightly below the limits of your breast frame, then you might as well go with the 450 cc since some patients do not in fact regret not having gone with a bigger choice when given the option. Having all this considered, share all your motivations for surgery, expectations and goals with complete honesty to avoid miscommunication and post-operative concerns/regrets. Be as specific as you can about what you like regarding your breasts and what you don’t like. If you trust your surgeon and their judgment and the decision-making method used to choose the implant size, then you should be in good hands. Hope this helps.