Why does my dysport fade after only 3 weeks?

Question

I have very deep forehead wrinkles and over my eyes. I alternate between dysport and Botox. Both seem to start wearing off after only a month. During the 2 weeks after injection. I would get no movement at all when I tried to raise my eyebrows. Now after only 3 weeks. I get movement and can see the lines. I do smoke, is this why it doesn't last very long on me?

Janet Allenby, DO · Answer

Hello,

Thank you for your question. There are several
explanations that range from improper placement, ineffectual dose/dilution, and
immunological difficulties. I recommend that you make an appointment with your
physician to discuss all of the treatment options possible.

Sanusi Umar, MD · Answer

It could be from over-dilution, bad batch or autoimmune rejection. It would be a good idea to consider trying either botox or xeomin next since they have a different molecular structure. Ultimately consult your injecting doctor.

Aldo Guerra, MD · Answer

Thanks for this question. It can happen, but it is not that common. Alternatives do exist for people with this issue. You should return with your injector and review your before and after photos. Smoking will make you look older and more wrinkled no matter what you do when compared to someone your own age who does not smoke. Speak with primary care about a cessation program. Good luck and best wishes, Dr. ALDO

Jason Emer, MD · Answer

It's rare, but some people can be fast metobolizers. You can try Xeomin as an alternative to Dysport or Botox. See an expert. Best, Dr. Emer

Dinesh Maini, MBChB · Answer

Dear Anne 
Thank you very much for your question.
I hope that you understand how toxins work: they kill the nerve endings that go to the muscles.
This is good - were they to stay dead you would have a lifelong result from one injection!!
They do come back to life and new nerve endings generate and this is when you sense it is wearing off.
My purely personal observation is that those that are very strong (ie have deeper lines to start with) start moving quicker. Also those who cannot stop themselves frowning etc find the effect wears off quicker.
The type of toxin seems to make less difference although in my hands I get best results with genuine Botox.
So I guess the rather unsatisfactory answer is that it is a bit like someone who bites their nails - you have to get out of the habit as quickly as possible and this will save you a fortune because the effect will take much longer to wear off.
I do hope this helps.
Kind Regards 
Dr Dinesh Maini

Omar Fouda Neel, MD, FRCSC, FACS · Answer

Thank you for your inquiry. Some patients metabolize the product more quickly than others. There are other options you can try such as Botox or Xeomin and see how you react. Please discuss these options with your board certified plastic surgeon.

Hardik Soni, MD · Answer

Thank you for your question. This is rare, but can happen in some individuals. There are alternatives for people who tend to metabolize Dysport faster. These alternatives are Xeomin and Botox. I recommend having a consultation with your injector to determine the best treatment plan for you.

Kristine Romine, MD · Answer

Thank you for your question.  There are several factors that could
influence the results of your treatments. 
Dysport and Botox are both neuromodulators (muscle relaxers) and therefore
have similar mechanisms of action. 
Typically, the results of both last about three to four months,
depending on the patient. The longevity of both of these neuromodulators is
dose dependent.  Another factor to
consider is injection of these products too frequently (less than two months
apart) which could increase risk of antibody formation causing the product to
be less effective.  It is well known that
patients who exercise a lot and eat a healthy diet, especially one low in protein,
do not have as long lasting results. You should also take into consideration
the expertise and training of your injector. 
The technique of injection is vital to an effective treatment.  It is best to seek a board certified
dermatologist or plastic surgeon who has extensive experience and training in
this field.

M. Bradley Calobrace, MD, FACS · Answer

While Botox and Dysport are very similar, there are some differences that exist.  Dysport does tend to allow a little more movement, which some patients prefer.  Regarding the duration of your injection, several factors may play a role including the dilution of the product or the dose given.  Without knowing these two factors, it is difficult to determine why your product is not lasting as long.  Repeated exposure, especially sooner than every 12 weeks, can lead to tolerance although this is rare.  My recommendation is to discuss this with your provider to determine why the product is not lasting the expected duration.

Wesley T. Myers, MD · Answer

Thank you for your question. There are several
explanations that range from improper placement, ineffectual dose/dilution, and
immunological difficulties. I recommend that you make an appointment with your
physician to discuss all of the treatment options possible.

Why does my dysport fade after only 3 weeks?

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