I'm 100lbs overweight, had Kybella twice, it's been months since and there's no improvement just low and jiggly skin. Advice?

Without photos it is impossible to say and it sounds as if you are not a good candidate for Kybella and that is the problem.  You should look into cool-mini which might be more appropriate if you have a larger amount of fat and not seeing any results.  Best, Dr. Green

My guess is that you are not an ideal candidate for Kybella. It will melt the fat, but if you have sagging skin then yes, it will make that condition worse. I would suggest that you schedule a consultation with a board certified plastic surgeon to discuss. My guess is that a surgical procedure would be better for you, but given your weight, that may not be a good option from a health stand point.