If you have a small amount of weight loss, then it is not likely there would be a significant change in your appearance. However, a larger weight loss may result in a hollowing of the under eye area and possible benefit of further Restylane placement. If you want to lose weight, do so, then return to your physician for an assessment.
It depends on what you call significant. 4 pounds will make a little difference in the overall look of the face and 8 pounds will produce noticeable difference. if you are talking about 10-20 pounds it is possible that the tear troughs will look more significant