Perlane Vs Juvederm Ultra Plus - Best Filler for Nasolabial Folds?

Perlane and Juvederm Ultra Plus are competitors and are designed to be an alternative to Retylane and Juvderm Ultra. They are all hyaluronic acid fillers, and so are not permanent, but both Perlane and Juvederm Ultra Plus are a bit thicker (more dense) so they last longer. In my experience, you can expect each to last anywhere from 9 to 12 months. I don't think there is a significant difference in terms of how long they last. What is more important is the technique of injection: if it is injected too deep, you will not really see much of a difference. If it is injected too shallow, then you may see some bumpiness or even some changes in the color of the overlying skin. So this is what I would recommend to you:
1) Either product will work well, as long as your injector is experienced
2) Ask to see some before and after photos of patients that the doctor has injected in the past
3) This area tends to be uncomfortable without some sort of anesthetic, either topical or an injection (I usually will numb the whole area well so that I can really mold the product into place once I inject it, so the patient will not be uncomfortable)
4) Don't be surprised if you need 2 or 3 syringes to get the desired effect, in particular if you have very deep folds
Hope that helps!
Dr. S

Perlane and Juvederm Ultra Plus are thicker forms of a dermal filler call Hyaluronic acid which are often used for deeper facial lines such as the Nasolabial folds (line from the nose to the lip sometimes called smile line) and marionette lines near the corners of the mouth. Although the competing companies that produce these fillers each claim their product is the best I have found them to be very similar. They usually last about 9 months with the first injection and depending on how deep the lines are one or two vials may be needed with each injection. Interestingly, I find with the second and third return visits patients need less volume and their results tend to last longer, so it appears you don't start over each time you are injected. Key Points: 1. Make sure your plastic surgeon numbs the area before injection. A dental block is easily applies and the procedure should be painless. There is no reason to suffer during these injections in this day and age. 2. Ask about experience with these products. The injector should use both frequently as lumps can occur if they are not injected at the correct level. (deeper than Restylane or Juvederm ultra) 3. If a lump occurs, don't panic. They can be easily corrected with massage or a simple injection of Hyaluronidase which dissolves the lump. 4. Overall my patients tend to be very happy with these two products and become repeat customers. 5. Sometimes when fillers are not enough a lifting procedure such as a cheek lift or Facelift may be a consideration instead of or in addition to dermal fillers

I recommend fillers to soften the nasolabial folds themselves and also lift around the mouth and cheeks to build underlying anatomical support. In our practice we combine Sculptra with other fillers "layered" on top and lasers, skin tightening treatments such as Thermage, Fractora, and Renuvion (J Plasma), thread lifting, and peels to get the most conservative, natural look. I suggest seeing a facial sculpting expert for a formal consultation. Best, Dr. Emer

Thank you for your question. They are both nice products with good longevity. Most times when nasolabial lines become deep it is a downstream effect from volume loss to the cheeks. The lack of support from above causes a deepening of the Nasolabial fold.  Often it produces a nicer result to treat the cheek area first, providing support. That is often enough to help reduce the NLF folds, or at least decrease the amount of product needed to soften the folds. This provides a much more natural looking outcome.

I prefer Juvederm for the nasolabial folds.  In most cases, the cheaper Juvederm Ultra is good enough.  But with certain people with heavier smile lines, I will use the Ultra PlusThe reason why I prefer Juvederm to Perlane in this area is that I have found that it attracts more water (hydrophilic) and I need to use less product.  Therefore, it can be more cost effective for my patients.

Juvederm ultra plus and perlane are
very similar. They are both hyaluronic acid fillers, tend to last
approximately 9-12 months and provide more volume than regular juvderm and
restylane. Your provider may prefer one of another but what matters most
is their injection technique and proper placement for optimal results.

Both products are hyaluronic acids but both are thicker versions of the smaller sibling, Restylane vs. Juvederm Ultra, respectively.  For nasolabial folds, either one is fine and if you're under the age of 45 it probabaly doesn't matter too much.  Juvederm Ultra Plus will give you 9-12 months and Perlane 15-18 months but expect a touch up at 4 months to make it last the full time.

Perlane and Juvederm Ultra Plus in the United States are the most robust hyaluronic acid-based, volumizing fillers currently available. In Europe, Canada and Israel, where I have a satellite practice, many other far more robust and longer lasting hyaluronic acid volumizers, such as Juvederm Voluma, Restylane SubQ and Stylage XXL are regulatory agency approved and available

Although Perlane and Juvederm UltraPlus XC may be used for similar purposes, I have found that owing to their particular gel characteristics, Perlane works better for giving lift to more deeply depressed areas and Juvederm serves better for achieving smoother contouring and blending. For that reason, I sometimes combine the use of both. For example, for the deep triangles on the sides of the nose, I might use Perlane L and for the remainder of the smile line Juvederm Ultra Plus XC. I might similarly inject Perlane L for the immediate corners of the mouth and Juvederm for the remainder of the marionette ("sad") lines. 

It is important to consult with a board certified aesthetic physician with experience using all the available materials. 

Both products can be used to replace volume loss, so it's a matter of personal choice. They both have comparable longevity and efficacy. Be sure you are receiving treatment from a well-trained and experienced injector and you should enjoy favorable results from either product.

Both Perlane and Juvederm Ultra Plus are good options for nasolabial fold lines. Both are longer lasting hyaluronic acid-based fillers with comparable texture, longevity, and safety records. You should go with whichever filler that your physician injector is comfortable with a price point that makes sense to you.

Both are excellent products with very similar applications, safety profiles, and duration.