Dear leno1:I love over the challenging questions my patients throw my way! This warning may be in the package insert but in day-to-day practice we have never seen an association. There are bacterial proteins in dust that can worsen asthma, for example. Reactions to dust are what we call IgE-mediated, which means the reaction to dust if one is allergic will be of the immediate-hypersensitivity type, eg wheezing, sneezing, coughing, runny nose, and/or itching, I have never seen someone nor have I read a report or warning that fillers may cause this type of reaction. Manufacturers must include in the package insert every possible reaction that might occur or has ever happened after a treatment or medication, whether causally-related or not. Having said that, if I had a patient with a dust allergy, a history of anaphylaxis, severe allergies, or multiple allergies, I would recommend a skin test with a small amount of the product, waiting at least 20 minutes to monitor for immediate hypersensitivity before proceeding. I also keep Benedryl as well as other antihistamine and an EpiPen in my office.All the best,Dr. Clark