I have had some improvement in reducing the vertical wrinkles above the upper lip that some patients have from dramatic pursing while speaking, or smoking. Others have it from bad sun damage. These lines are related to the muscle movement of the mouth during speaking or eating. Although many aggressive treatments including dermabrasion, fully ablative carbon dioxide laser resurfacing and deep chemical peels, which are not done commonly any longer, helped reduce these lines, they would in fact be seen to return with continued muscle contraction during the years after the procedure is done. Ultherapy delivers focused deep energy of ultrasound and heats the dermis. I have been using the 1.5mm. deep transducer in this site of the upper cutaneous lip for some time. However, my patients know after I discuss the treatment with them in consultation, that not only is it not a cure and that some lines will remain and some recur, but no physician can guarantee an improvement. Some patients won't see the good results others do obtain. The information provided in Dr. Shelton's answer is for educational purposes only and is not intended to constitute medical advice. The information provided should not be relied upon as a substitute for consultations with a qualified health professional who may be familiar with your individual medical needs.