How long (once opened) can Hyaluronidase be used to dissolve lip filler? And once expired is there no effect? (Photo)

Longterm filler problems include migration, edema, and nodularity. Filler migration and permanence is a very common problem because there are many different types of HA fillers on the market and each is specified for a specific part of the face. Use of highly cohesive fillers on thin skin may cause swelling and nodularity. If patients have filler migration or nodules, we recommend a combination approach of filler reversal with enzymes Hylenex and Hyaluronidase in different strengths to dissolve the filler. We may also need to add Kenalog to the mix in order to reduce fibrous tissue. If the filler does not dissolve, it either means the filler is not HA material or we need more enzyme. The HA reversal can be combined with other lasers and skin treatments at the same time, and it usually (usually) does not affect adjacent tissue.

Best,
Dr. Karamanoukian
Realself100 Surgeon

I suggest seeing a board certified dermatologist as this hyaluronidase is not a common one used and the filler you describe is not FDA approved.  Best, Dr. Emer.

I recommend that you see someone that uses the trademark product Vitrase. Dr H Karamanoukian#rRealSelf100 Member