How can I get rid of a frown line that cannot be relaxed by Botox? (Photo)

Once lines become deep enough, Botox cannot make them completely disappear. You have a permanent change to the underlying skin and need to volume augmentation to smooth it out. This can be safely done with filler, by someone who has a good understanding of the blood vessels in this area. The location of your particular line is right above some large blood vessels and a nerve coming from your eye socket. Filler would need to be injected superficially here to avoid injecting into the vessels.

This is one of the areas where placing filler has a higher risk of vascular occlusion (see my link).  Make sure the doc has done this area multiple times in the past.  It won't eliminate your need for Botox as well.