Rejuran hyper reaction with old filler?

I have a question the potential for “hyper reactions” between Rejuran (Healer / HB) - if I had fat graft and HA filler as Restylane (which I believe is cross-linked) more than 1 year ago, but the effect of both still remain, is there any potential for such hyper reaction? Or is the skin layer different? Because my understanding is that both is in the dermis layer, but Rejuran is in the superficial dermis while How is this hyper reaction presented, and how soon would it be seen after treatment?