Hello and thank-you for your question!Cellfina is the latest break though for the treatment of cellulite. Cellfina targets the fibrous bands which are the source of the dimpling in cellulite. It is most effective for the treatment of dimples and depressions of the buttocks and outer thighs. Once released, the cellulite should not re-occur in the treated area. As with all body contouring procedures, the goal should be maintenance of your weight through healthy lifestyle changes, including diet and exercise. Significant weight loss may cause worsening of skin laxity, but should not affect the Cellulite in Cellfina treated areas. Significant increase in weight should not affect the appearance of cellulite in Cellfina treated areas, but may cause cellulite to appear in untreated areas. Minor weight fluctuations should not affect your results. The results for Cellfina are long-lasting with an amazing two year patient satisfaction rate of 96%! Cellfina is a relatively new technology and on going studies will further clarify the long term benefits of Cellfina.Best regards,Andrew Lyos MD, FACS