Will semaglutide make my lipo fibrosis worse when I lose weight?

The semaglutide would not directly affect the fibrosis that concerns you. However if you lose fat in the liposuctioned area the current fibrosis may become more visible. See your provider for further clarification if needed.

I don't see any way semaglutide will have any direct affect on fibrosis after lipo. There's a chance it may become more visible, however, if you lose a lot of fat around the fibrosis.

To our knowledge there is not currently significant data regarding semaglutide and lipo fibrosis. That said, weight loss from semaglutide is essentially due to caloric deficit, and thus does not involve the physical inflammation or edema that can sometimes lead to lipo fibrosis.