What is the difference between compound semaglutide vs ozempic?

If the compounding pharmacy uses semaglutide base, which they are supposed to, it is essentially the same as ozempic. I've prescribed compounded versions to hundreds of patients with no issues.

Hello and thank you for your question! Ozempic is the FDA-approved brand-name version of semaglutide, made by Novo Nordisk with strict quality control.

Compounded semaglutide is not FDA-approved, but it can be very safe when made by a reputable compounding pharmacy. The key is that your provider does their research—using only trusted, accredited pharmacies that follow high-quality standards.

Should you worry?
Not if you're under the care of a knowledgeable provider who ensures the compound is the correct form (semaglutide base, not salt) and comes from a certified pharmacy. When done right, many people use compounded semaglutide safely and effectively.

If you’re 25 lbs overweight, you may qualify for Wegovy (FDA-approved for weight loss), but compounded versions can be a good alternative when prescribed responsibly.

Best of luck!
Genie Alexander, RN BSN
for Anna Petropoulos, MD FRCS
Center for Classic Beauty
Boston & Danvers, MA

The medications are essentially identical. The generic name of the drug is “semaglutide” which the FDA allows compounding pharmacies to produce since ozempic is on the FDA shortage list. Ozempic is a brand name, with the active ingredient being semaglutide. The cost of Ozempic is therefore 2-3 times higher than the generic semaglutide that you can obtain through a compounding pharmacy. Both medications have similar effects and similar side effects. If you would like a more detailed description of the risks, benefits and what to expect from these medications, click on the link below.
I hope this is helpful.

Best wishes,
Dr.Bruno

The drug semaglutide is FDA approved. The brand name Ozempic is made by the company Novo Nordisk. If a compounding pharmacy is a 503B, it is highly regulated. In fact, many hospitals and outpatient surgical centers order drugs from 503B compounding pharmacies. The problem arises when the compounders use the salt form of semaglutide. This has actually been banned in some states. With the recent shortages (even for diabetics) of drugs such as Ozempic and Mounjaro, legitimate compounding pharmacies have been increasing production to meet the demand. In my experience, it can be difficult to get a Rx for Ozempic filled if there is no proof of diabetes. This is why many have turned to compounding pharmacies and are willing to pay out of pocket. If you chose a reputable componding pharmacy (you can actually look them up on the FDA website) you will be fine. Whether compounded or obtained by the company, they have similar side effect profiles and must be dosed properly to mitigate these symptoms. I hope this helps! Dr. Dima

Both ozempic and semaglutide are approved by the FDA, the substance is the same, and with the drug you would lose between 15 and 20 pounds, and with risks and anaplastic thyroid cancer, it is something to think about.

Ozempic is a brand name for the GLP-1 medication semaglutide. Compounded semaglutide would have the same side effects as Ozempic,. Patients are often able to obtain the compounded formula for far less than the brand name Ozempic.

Ozempic is approved as an adjunct to diet and exercise to improve glycemic control in adults with Type 2 Diabetes mellitus. Ozempic is a branded semaglutide product manufactured by Novo Nordisk. Compound semaglutide is produced at specialty pharmacies and thus is not FDA approved for safety, effectiveness, or quality.

Compound pharmacies that are FDA approved can produce Semaglutide but with a vitamin attached to the molecule. They are the same as the branded products such as Ozempic and Wegovy with the same side effects and efficacy profile. Compound semaglutides are equivalent to generic form of the branded medicine.