Ozempic use after facelift and revision?

Question

I have been taking Ozempic for diabetes and have only lost 5 pounds but I have Ozempic face. I’m not taking it for weight loss. If I have a facelift, will resuming Ozempic after a facelift cause Ozempic face again or should I seek out a different diabetes medication. Help my doctors don't know, I'm concerned.

Anna Petropoulos, MD, FRCS · Answer

Hello and thank you for your question. "Ozempic face" refers to facial fat loss, often due to weight loss on semaglutide. However, even with minimal weight loss (like your 5 lbs), some patients experience disproportionate facial volume loss, likely due to individual fat distribution or sensitivity.
A facelift will tighten and lift tissue, but it won’t prevent further volume loss if the underlying cause (Ozempic) continues. So yes—resuming Ozempic after a facelift could lead to recurrence of facial hollowing.
If you're not getting significant glycemic or weight benefit from Ozempic, and cosmetic effects are concerning, it’s reasonable to consider switching to another diabetes medication. Options include:
Dulaglutide (Trulicity) – another GLP-1 with less facial fat loss reported
SGLT2 inhibitors (e.g., Jardiance) – weight-neutral or mild loss
DPP-4 inhibitors (e.g., Januvia) – weight-neutral
Discuss this with an endocrinologist and, if planning surgery, a facial plastic surgeon familiar with GLP-1 effects.
From the non-surgical perspective, treatments like RF-microneedling and Sculptra can combat or even prevent some of these Ozempic-related changes- that may be worth looking into!

Best of luck!
Genie Alexander, RN BSN 
for Anna Petropoulos, MD FRCS 
Center for Classic Beauty
Boston & Danvers, MA

Peter D. Geldner, MD · Answer

The term Ozempic face has been used frequently in the recent past. While we all understand what that means, it is simply what happens to most people with rapid or major weight loss. So to rephrase your question; Would loosing weight after a facelift change the facelift result? The answer is: it depends. Different facelift techniques and different faces have somewhat different susceptibility to weight loss. But would mild weight loss make you look worse? Probably not. I would suggest that you seek a consultation with a board certified plastic surgeon who is fluent with various methods of performing face lifts. They will likely give you the best advice moving forward.

Camille Cash, MD · Answer

"Ozempic Face" is typically a result of rapid fat loss.  This can occur in the face or the body.  If you have a facelift and continue to use Ozempic and lose weight it is possible it could affect your results.  There are treatments available to help "Ozempic Face" such as HA fillers, Sculptra, Renuva, or Morpheus8.  You can learn more by visiting my website or a provider near you.

Navjot Singh, MD, FACG · Answer

Thank you for your question. Ozempic causes weight loss and changes in the facial look because of decreased facial fat "Ozempic face." If you plan to continue using Ozempic after the facelift, your doctor can determine if the benefits of Ozempic for managing your diabetes outweigh the possibility of result changes. Also, dermal fillers can effectively restore volume and improve facial contours. A higher G prime filler is often injected deeper to replace the deep fat pads. In contrast, a softer, less cohesive hyaluronic acid filler may be used superficially to smooth out contour changes. A comprehensive assessment is important to determine the best treatment plan for your needs.

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