I have one armpit that is a lot fatter than the other armpit. It is on my right side which is also the side with the larger breast, but nothing drastic. I first noticed this about a year ago after I had gained about 15 pounds but I brushed it off. Lately it has been worrying me since it is so much bigger than the other side. I can't feel any lumps, to me it feels just like fat. It isn't painful, but when my arms at at my side I do notice more pressure in the area and it's slightly uncomfortable.
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