Fortunately there are many safe and effective options for treating cheek folds. The most popular treatments are soft tissue fillers, Sculptra and abdominal fat transfer.Soft tissue fillers (Radiesse, Voluma, Juvederm, etc.) were the second most common minimally-invasive cosmetic procedure in 2012 and over 2 million procedures were performed (American Society of Plastic Surgery Statistics). Many products are available and they are all reasonably effective. The advantage of using fillers is that the results are immediate and the materials typically used are found naturally in your body. The disadvantage is that fillers can be expensive and typically only last about 1 year.Sculptra differs from soft tissue fillers in that it works by stimulating your body's collagen-producing machinery. Consequently, results are not seen immediately, but rather grow over a period of several months. Results are perhaps a little less dramatic than soft tissue fillers, but last up to 2 years. For best results, 3-4 treatments are required.In abdominal fat transfer, your own fat cells are gently harvested from your belly. These are then carefully washed and injected into areas of volume loss (in this case, your cheek folds). The advantage of fat transfer is that living tissue is transferred. Those cells that survive the process will be present forever! However, around the mouth the survival rate is rather poor, so more than one treatment may be required.