What is the best way to remove nasolabial folds? (Photo)

The presence of the nasolabial fold is a normal process that occurs with aging beginning in the fourth to fifth decade of life. When you look at the nasolabial fold you have to look at it as a process of cause and effect. The cause is loss of support in the cheek region that are keeping the fold from folding over upon itself. The second cause is loss  of volume medial to the fold or closer to the nose. The effect is loss of volume with ensuing hollowing and depth to the region.  This can be treated by supporting the cheek by lifting or volume replacement or by filling the hollow with either autologous or synthetic products. I hope this helps. 

Best means something different to different people.  One approach is to cut the extra skin out, this leaves a scar but could be done under local.  You appear thin in the face and so fat grafting could be an option.  Facelift is also an option.  Each option has risks, scars, recovery and costs, so it is worth a consultation with a board certified plastic surgeon.