Allergic reactions to Radiesse are quite rare. Typical adverse reactions include localized hypersensitivity reactions, injection site inflammation which typically resolves spontaneously within one to two days, and inflammatory nodules known as granulomas. A granuloma will take six to twenty-four months to form after the injection. The allergic reactions you describe are immediate, systemic hypersensitivity reactions which, to my knowledge, have not been reported with Radiesse injections. Typical side effects associated with Radiesse injections include bruising, redness, swelling and pain. These occur in as high as 90% of patients and usually resolve within one week.