With a 46P breast size, a significant reduction is usually possible, but the smallest safe size depends on your anatomy, breast width, nipple position, blood supply, skin quality, body frame, and how much tissue must remain to keep a healthy breast shape. There is no exact cup size that can be promised before an exam. Cup sizes are also very unreliable between bra brands. A surgeon can estimate grams to remove from each side, but the final cup size cannot be guaranteed. For very large breasts, getting extremely small may require a free nipple graft. This allows more tissue removal in selected cases, but it has important trade-offs: loss of nipple sensation, loss of breastfeeding ability, possible pigment changes, and a flatter nipple/areola appearance. If you want to stay with a pedicled reduction, where the nipple remains attached to tissue and blood supply, the surgeon may need to leave more breast volume for safety. That can still create a major improvement in weight, pain, rashes, posture, and clothing fit, but may not get you to the smallest possible size. My advice would be to consult a plastic surgeon experienced in very large breast reductions. Ask what size range is realistic for you, how many grams may be removed, whether a free nipple graft is likely, and what balance they recommend between maximum reduction, nipple safety, shape, and long-term comfort.