Would getting Botox after two months cause me to develop a Botox resistance?

Question

I got botox 2 months ago on my crow's feet. I want to get my jelly rolls injected now. Will doing it after 2 months cause my body to form antibodies against botox?

Kenneth Hughes, MD · Answer

Hello, thank you for your question. This is an excellent question about an issue that does cause some confusion. Some patients may believe they will build up resistance to the effects of Botox if they get multiple treatments. This is a rare occurrence. Actually, the results of Botox injections tend to last longer for patients who have already had several treatments.

James R. Gordon, MD, FACS, FAAO · Answer

Thanks for sharing your question. It is ok for you to receive Botox injections every 2 months. It is unlikely to develop antibodies to it. Good luck with your treatments!

Dhaval M. Patel, MD · Answer

Thank you for your question! Repeating botox every two months will not make your body produce antibodies against botox.  Best of luck to you.  Dr Dhaval Patel 
Plastic Surgeon 
Double Board Certified 
Chicago
Hoffman Estates 
Oakbrook 
Orland Park

Brandon Richland, MD · Answer

No getting another injection in two months will not cause your body to form antibodies against botox. I have offered repeat "touch up" injections as soon as 2 weeks after the first treatment if necessary

Tim Neavin, MD · Answer

Thank you for your question. Having Botox two months after a previous treatment should not increase your risk of Botox resistance.

Nelson Castillo, MD · Answer

Thank you for sharing your question.  No previous Botox to your crow’s feet will not lead to resistance.  Hope this helps.

Christopher Hankins, MD · Answer

Formation of antibodies to Botox is rare. However, the presence of antibodies has been attributed to shorter dosing intervals of 2 months, booster injections, higher doses per injection cycle, and higher amounts of antigenic protein. Botox is a foreign protein to the body which may result in the formation of antibodies, but again, this is rare.In consideration of the above, I would refrain from too frequent treatment with Botox and to use the lowest effective dose for your needs. In summary, the risk of development of antibodies to Botox is low, but greater than zero. Hope that this helps.

Lesley A. Rabach, MD · Answer

Repeating Botox treatments sooner than 3/4 months will not cause your body to form antibodies against the treatment. 
Even having more injected after one week will not cause your body to form antibodies against the treatment.

Julie Shelley, DO · Answer

Hello, and thank you for your question! Having Botox injected two months after a prior treatment should NOT increase your risk of Botox resistance.  Botox resistance is fairly rare but can occur, typically after years of having Botox injected.  
- Dr. Shelley
Oklahoma City, OK

Camille Cash, MD · Answer

You will not increase resistance to Botox by having a treatment two months after a prior treatment.  Botox resistance can occur, but is fairly rare.  Botox final results are seen two weeks after injection and the results gradually fade over 3 to 4 months.

Would getting Botox after two months cause me to develop a Botox resistance?

Answers (14)

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