Does Spironolactone have an initial breakout phase?

Spironolactone is a great oral treatment for hormonal acne. While it is true that there can be a breakout when its first initiated, there are things that we can do to try to minimize the initial breakout. One option is to simultaneously take oral antibiotics to try and reduce the bacteria on the face and help control the breakouts. Another option is to get cortisone injections initially while we are waiting for the Spironolactone to kick in. Spironolactone is a great option for hormonal acne and most patients feel that the initial breakout is worth the great results they get on the medication.