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2% hydroquinone is a good starting place. The prescription level in the US is a 4% HQ, and your doctor can have a compounding pharmacy create a higher dose, like a 6% or 8% if needed. I find that people who do not respond to the HQ usually just need a higher dose. Don't use it long term--it is best to cycle it if you need to use for more than 2 or 3 months.As an aside, get the moles checked out before you start lightening them and changing their color. You don't want to inadvertently treat a skin cancer and delay its diagnosis.Best of luck to you,Dr. Amy