Hi! Great question. HPV is a virus that is commonly associated with the genitalia and could cause female gynecological cancers such as cervical and is the culprit behind genital warts. It is usually sexually transmitted. In a 'vampire facial', microneedling is preformed (small microscopic punctures of your skin) and then PRP (a component from your own blood) is placed on the skin for 'wound healing' thus increasing collagen and elastin. Your are not a risk for getting HPV when getting a vampire facial. Now, if you have a history of herpes simplex virus (HSV) I may ask that you take suppression medications before the procedure. Triggers for HSV flareups may differ from person to person so to error on the side of caution, I typically will prescribe valtrex. Most important is that you go to a medical office that takes all the necessary precautions when handling the PRP and performing the microneedling. Example, the cartridge of needles used in microneedling should be a one time use and disposed after each use with a patient. So you should always be getting a brand new one. Needles used to draw your blood should be new and sterile. Good luck & hope I've helped answer your question. Dr. Huo