I think one of the most telling ways to tell if a therapy is "the best" is to survey what "doctors do" when they need a treatment. I will tell you that whenever physicians have a basal cell or squamous cell carcinoma on their nose, Mohs seems to be their first choice of treatment. This hopefully adds some insight. But more importantly are the long-standing, successful cure rates of Mohs Surgery. As stated in prior responses, Mohs Surgery provides a 99% cure for basal cell cancers, and a 97% cure for squamous cell skin cancers. However, there are many alternatives to treating skin cancers on the nose that should also be considered; those treatments range from traditional excision, to topical chemotherapy creams, radiation, scraping and burning, lasers, photodynamic therapy, and newer immunologic oral drugs. Having a dermatologic professional at your side should help you tease apart what the pros and cons are to each option for treatment.