Will the Fraxel lasers interfere with fillers?

I would do Fraxel laser first and wait for 21 days until complete healing is done. Then do fillers of any kind.

Many of the dermal fillers used in the U.S. are partially dependent upon their water attracting properties to provide their effects. All the hyaluronic or HA gel fillers like the Restylanes and Juvederms work by attracting water and “expanding”. They carry the most vulnerability to heat-based treatments because the heat can diminish the water content in both the skin and the filler if the heat reaches the filler. Other fillers like Radiesse are calcium based and are injected deeper in the skin and are less likely to be affected. 
The depth of the filler placement and the depth of the heat generated by a laser can affect how long the filler might normally last for you. Also the type of technology will impact fillers. Deeper-reaching heat would pass through some fillers. For instance, a superficial placement of a filler would be extremely vulnerable to a laser like Fraxel and you would likely see less correction of treated wrinkles right away.
So to summarize, it is always advisable to have the Fractional procedure then do the dermal fillers a few days later. If this is not an option then wait towards the end of your filler’s life cycle to have your fractional CO2.