How effective is PRP/ PRF for people who takes paracetamol/ ibuprofen regularly?

The use of anti-inflammatories such as Ibuprofen, (a non-steroidal anti-inflammatory, NSAIDs, will negate the benefit of PRP. It's recommended these be avoided for 6 weeks post procedure. You can take Tylenol instead.

As of my last update in September 2021, the use of Tylenol (acetaminophen) and corticosteroids in conjunction with platelet-rich plasma (PRP) treatment is a subject of discussion and research. While some experts have concerns that these medications might interfere with the healing process promoted by PRP, the scientific evidence is not entirely clear.
Platelet-rich plasma therapy aims to use growth factors and cytokines released from platelets to promote tissue healing and reduce inflammation. Corticosteroids, on the other hand, are anti-inflammatory agents that may suppress the local immune response, which could theoretically inhibit the effects of PRP. Some clinicians worry that steroids may dampen the body's healing response that PRP is intended to activate.
Tylenol is primarily used for pain relief and has a different mechanism of action from corticosteroids. It is generally less controversial in combination with PRP, but there is still some concern that it could potentially interfere with the body's healing mechanisms.
Here are some points to consider:
1. Mechanisms of Action: Understanding the mechanisms of action of PRP, corticosteroids, and Tylenol could help predict potential interactions. However, the complete mechanisms are not yet fully understood. Cytokines often function in the swelling and cell recruitment process following a procedure. Growth factors are going to stimulate cells, growth, and repair. The medications you are concerned about do not interfere with the beneficial aspects of PRP, in my opinion. No patient complains if they swell less following any medical or surgical procedure.
2. Short-term vs. Long-term Effects: Steroids often provide quick relief from inflammation but may have long-term consequences on tissue repair, potentially affecting the benefits of PRP.
3. Individual Variability: Patients may respond differently to these treatments, making it challenging to issue universal guidelines.
4. Clinical Trials: More robust clinical trials are needed to definitively prove or disprove whether these medications significantly inhibit or enhance PRP's effects. These trials do not exist
5. Expert Opinion: Always consult a healthcare provider for a personalized treatment plan, especially if considering multiple interventions. I think the benefits of PRP are not negatively impacted by non-steroid anti-inflammatories or paracetamol. I do not discourage my patients from using these products before or after a PRP treatment. The most important consideration is the choice of the right provider and PRP system for the condition you seek to treat.
If you are considering PRP treatment, it's crucial to consult your healthcare provider for advice tailored to your specific medical condition and treatment objectives.

Paracetamol (acetaminophen) is generally considered safe and does not have known interactions that significantly impact the efficacy of PRP/PRF treatments. However, it's always a good idea to inform your healthcare professional about any medications you are taking, including paracetamol, prior to undergoing PRP/PRF therapy.