The cause of the wrinkles between the eyebrows is overactivity of the muscles that cause the skin the fold and give the scowl or concerned appearance. For that reason, the first line treatment is usually relaxing the muscles with Botox or dysport. Fillers (such as Juvederm) alone do not work as well, but may be useful in addition, when the wrinkles have been there long enough to be "etched" in..
Juvederm or any fillers can be used for frown lines but they are not my first choice. Botulinum toxin is superior despite the fact that it needs to be repeated more often.
