Can Hyaluronidase Be Used Incrementally to Avoid Dissolving All of the Juvederm?

Question

I had Juvederm injected in my tear troughs over a month ago which caused major swelling and the Tyndall effect. Is there any way only some of the Juvederm can be dissolved if the hyaluronidase is injected slowly over the course of an hour or so? Thank you.

Otto Joseph Placik, MD · Answer

IT is difficult to quantify the effects of hyalturonidase and using dilution of the product, one could administer extremely small quantities but to some degree you will get an all or nothing response.

Richard H. Tholen, MD, FACS · Answer

Since hyaluronidase works by enzymatic breakdown of the Hyaluronic acid (HA) fillers, the degree and amount of dissolution is related to the amount of the original HA filler and its original injection technique (tiny amounts placed in microdroplets within the target tissues--the preferred method), or larger blobs and lumps (unfortunately all too common), as well as the concentration and the amount of the hyaluronidase injected. With all these variables, you can see why the correct answers tell you that it is difficult, but not impossible, to "just take a little off the sides." Precision with enzymatic removal may not be a reasonable expectation from an injector who gave you "major swelling" in the first place.

	Precision and conservatism in the original injection of HA fillers is preferable to trying to precisely remove SOME of the (expensive) filler.You can always add more, but it's much harder to take away smoothly and evenly.

Ron Shelton, MD · Answer

It is possible that small doses of hyaluronidase can be used and to follow and a later date with more so not all filler is dissolved at one time.

Richard Baxter, MD · Answer

In my experience the hyaluronidase enzyme typically removes all of the filler and can't be controlled for partial removal with any precision. It sounds like you may be better off by going to a different filler or fat grafts so as to avoid the Tyndall effect.

Benjamin Barankin, MD, FRCPC · Answer

Hyaluronidase is a useful agent to dissolve the hyaluronic acid fillers such as juvederm and restylane. It can be injected carefully & incrementally in small doses, with reassessment 2 weeks later. More can always be added, and this way you don't dissolve all the filler.

Can Hyaluronidase Be Used Incrementally to Avoid Dissolving All of the Juvederm?

Answers (7)

Answer: Hyaluronidase removes HA fillers completely

Answer: Hyaluronidase removes HA fillers completely

Answer: Using hyaluronidase carefully & incrementally

Answer: Using hyaluronidase carefully & incrementally

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Everything you need to know about Hyaluronidase

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Can Hyaluronidase Be Used Incrementally to Avoid Dissolving All of the Juvederm?

Answers (7)

Answer: Hyaluronidase removes HA fillers completely

Answer: Hyaluronidase removes HA fillers completely

Answer: Using hyaluronidase carefully & incrementally

Answer: Using hyaluronidase carefully & incrementally

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Recommended reading

Everything you need to know about Hyaluronidase

Our mission is to create a world where every investment in modern beauty is Worth It.