This is a fantastic question, although the answer will depend on which surgery you're planning to undergo which I don't see included in your question above. In general you are correct, Exparel has replaced the use of pain pumps in many circumstances (universally in my practice) and is great because you don't have a pump coming out of you after surgery. Also, Exparel can be injected into many different locations instead of dripping into just one area like the pain pump does. Exparel is an amazing drug, that has completely transformed post-operative pain and recovery in my patients undergoing breast and abdominal surgery. In breast cases I uses it to numb all the nerves in between the ribs so both chests are covered and in abdominal cases inject in many locations, essentially numbing the whole abdomen. For cosmetic cases, most surgeons will charge extra since it is very expensive, but the patients say they'd easily pay double after experiencing the effect vs what is typical with their respective surgery. I've never personally used or heard of anyone using exparel and a pain pump - to me that seems unnecessarily redundant, wasteful and a hassle for the patient.Regarding your specific situation, don't worry about your acetaminophen (tylenol) allergy. It's the least powerful pain medicine there is. Most narcotics come as a combo with it, however the narcotic medicine alone can be prescribed to avoid the acetaminophen. In addition to narcotic pain meds, I always write my breast and abdominal patients for valium which is a muscle relaxant and really helps with the muscle spasm and discomfort after surgery - many patients in fact say this is more helpful than the narcotic. The combination of these 2 drugs should be more than enough (especially if Exparel is used). You could also potentially take ibuprofen (motrin/advil) a few days after surgery, but you would need to clear this with your surgeon beforehand since it can cause bleeding in certain cases.Overall, I can't recommend Exparel enough, if it were me or a family member I wouldn't consider major breast or abdominal surgery without it. And for your post-op pain control, you'll be more than fine even though you can't take acetaminophen due to your allergy. Best of luck!