Risk of Latisse causing older-looking eyes?

Assuming that you follow the instructions and apply latisse correctly, you shouldn't have a problem. The condition you are referring to is related to patients who are using drops for glaucoma. Which go in the actual eye. Not along the lash line. Best, Dr. Nazarian

Latisse is meant to be applied around the eyelashes and should not be associated with the side effect that you are describing.  Please consult with your physician before starting Latisse to see if there is any contraindication for you.

The side effect that you are referring to is called Prostaglandin Associated Periorbitopathy (PAP).  Although not entirely rare, this condition appears to be more of an issue in patients using the glaucoma drop form of Bimatoprost on a regular basis.  It also appears to be a more noticeable side effect in patients who are using the medication in only one eye.  That being said, in cases of PAP, discontinuation of the medication typically results in partial to complete reversal of the PAP characteristics as quickly as 4-6 weeks after stopping regular usage. 

Periorbital lipodystrophy (fat loss) is a rare, but documented side effect of long-term use of Bimatoprost eyedrops used for the treatment of glaucoma.  These drops are placed directly on the eyeball. Latisse, if applied correctly, is placed directly on the skin of the eyelid.  Periorbital fat loss is also part of the natural aging process.  Consult your prescribing physician prior to using Latisse. I hope this helps.