A negative effect of fat grafting that I am seeing more and more of is over-filled faces. Fat grafting should look natural. If it looks like fat grafting, in my opinion, that is a problem. The Realself fat grafting before and after gallery includes some examples of what I believe to be natural looking results from fat grafting. With the transfer of any living material, whether it is fat grafting or the grafting of solid tissue like dermis/fat or fascia/fat, it is intended that some of the transferred material gets revascularized and survives. The majority of the transferred living tissue that does not get revascularized is broken down by the body's natural scavenger cell system. Meticulous surgical technique, patience and attention to detail are required on the part of the surgeon to maximize the proportion of the grafted tissue that persists as living tissue, regardless of what type of tissue the surgeon is transferring. I have seen no cases of palpable oil cysts or chronic inflammation in any patient for whom I have performed structural fat grafting, and have had no cases of postoperative infection. As with any cosmetic surgery, meticulous technique and attention to detail on the part of the surgeon can produce beautiful, natural-appearing results - whether it's a facelift or fat grafting or a breast augmentation. In the right hands, structural fat grafting of the lower lid / cheek junction can produce a natural-appearing, and youthful contour. In inexperienced or impatient hands the result can be lumpy and even disfiguring. So make sure that the surgeon you are seeing is board-certified, has a lot of experience with fat grafting, and can show you photographic examples of the surgery in which you are interested. The lower lid / cheek junction is a challenging area, as the skin is thin and the orbital rim (bone) is immediately below. So there is less margin for error compared to thicker soft tissue areas like the cheeks and jawline. It is certainly not an area for a surgeon to start with if he/she is just learning fat grafting surgery. With lower lids a surgeon cannot afford to 'overdo' it, for if you overfill this area (because you expect that some of the fat will not persist) you may be left with excessive fatty fullness if most or all of the fat survives. So when treating this area I feel it is critical to add fat up to the point where the contour looks ideal, then stop. If most of the fat survives, great; if it does not then you come back 3 to 4 months later and add some more (by 3-4 months any non-vascularized fat has been reabsorbed). I let all patients having lower lid / cheek fat grafting know that there is a pretty good chance that they will need/want a secondary fat grafting procedure to enhance the result in this area. I have never regretted taking a cautious and conservative approach with this area.