Hello and thank you for this question. I look forward to sharing with you my recommendation for micro needling serum. While almost any serum can be used, why not use the best option. My serum is Omni Bioceutical Innovations human growth factor serum. It is nearly 100% pure, free of irritants, has antimicrobial properties and is derived from actual skin cells, not fat, bone marrow, platelets, placenta, bone or other human tissues. Actual skin cells are going to be the most effective at sending a message to another skin cell. Our serum can be used on an open wound...different from many other skin cell products because of the other actives in it. Most growth factor serums are not patented. The process that purifies and concentrates all the antiinflammatory factors is why I use this product over a multitude of others on the market. I have used in on cuts, ulcers, open cysts and acne and in 9 years have never had a reaction. I would not, at this point in time, do micro needling any other way. Best of luck! Sincerely, Valerie Schneider MD