I've got downturned lips with pockets around smile lines. Best option for fuller lips and removal of smile pockets? (Photo)

You look like you are a great candidate for fillers.  Juvederm would be the best option to increase the fullness in your lips.  You can also inject at the corners of your mouth to help your mouth turn up instead of down.  Juvederm will last on average 8-12 months.  It always best to seek a consultation with a board certified plastic surgeon in your area. 

The issue, is lack of volume and support, Fillers and Botox can offer that to you. If they work and you like the results, you could consider fat grafting.Good LuckStephen M. Davis, MD, FACSGreen Hills Plastic Surgery

I think a combination of fillers to support the corners of the mouth, and possibly into the cheek bones to lift the skin can be quite helpful. As well, possibly some Botox in the DAO muscle can be used. Both juvederm and restylane can do a great job on this, best to chat with your dermatologist as to the best options for you.