You could, but it is far from the best option. Neosporin is heavily occlusive and block pores and there should be no need for a routine antibiotic ointment after a laser - it's just extra ingredients that your skin can have a reaction to.Talk with your treating doctor's office. Depending on your skin and the treatment you are undergoing, they are the best source for what postcare is best for you. Most importantly, be gentle with your healing skin and avoid sun exposure after treatment.