I have autoimmune components and Sculptra doesn't seem to be taking. What other options are there to restore volume in the face?

You can use sculptra as your base and then other fillers on top to get a more improved outcome. If you really need a lot of volume, fat injections may be best. 2 Vials is VERY little, in patients like you, 6-8 vials will be needed at the beginning and then a number of vials each year along with others fillers, fat or PRP.  Please see an expert. It takes 3 months to see the results of even the first vial, have patience.  Dr. Emer

Options other than Sculptra or Voluma to add volume to the face would include Radiesse, Bellafill, fat transfer and surgically placed implants.  

Sculptra is a wonderful volumizer, and in your age should have a great response. However, great majority of patients need 2 to 3 sessions of sculptra treatment, with 2 vials being injected each time. If you have severe volume loss throughout your face, you may need even more treatments. Sculptra works through the process if collagen production, which can be achieved overtime. Sometime for more immediate gratification I add other fillers such as restylane until Sculptra takes effect. Remember to massage your face for 5 days after each Sculptra treatment to increase collagen production. Best of luck!