I have personally been treating the marionette lines (aka "sad" lines, downturned angles of the mouth) since the early 1980s with the original Zyplast collagen fillers. We have fortunately come along way since those days when we simply "chased" after lines and folds, like the marionette lines, by simply filling them up with whatever filler du jour was available at the time.Nowadays, owing to our far more sophisticated understanding of the aging process in the face, particularly to the effects of bone, muscle, and fat loss, we attempt rather to re-contour, reshape and rejuvenate the face by restoring volume to areas that have lost it with the passage of time. It may seem counterintuitive, but the marionette lines result in the main from facial volume loss within the cheeks above. This means that restoring the volume to the cheeks with a volumizing filler, such as Voluma XC or Radiesse Plus, can result in significant uplift and improvement in the marionette lines--without even directly injecting them. To understand this better, you may wish to search the archives of RealSelf. com for The Nonsurgical 3D Vectoring Facelift. What is important is that you seek consultation with a board certified aesthetic physician with experience in the many nonsurgical methods for facial rejuvenation using volumizing fillers. Make sure to ask to see his/her before and after photos before proceeding.