Can glutathione and hydroquinone be used together?

Question

Hello, I have a question. Can glutathione and hydroquinone be used together, or do they have adverse effects against one another? If they do, then can I supplement glutathione after I am finished with hydroquinone to maintain results? I am looking for a doctor who knows about skin lightening in hope of working with them on my skin.

Anna Chacon, MD, FAAD · Answer

Glutathione and hydroquinone are both substances used in skin lightening products. Glutathione is an antioxidant that's naturally produced by the body, while hydroquinone is a synthetic compound.
Glutathione is often used in oral or injectable form to achieve a systemic lightening effect, while hydroquinone is typically used topically for spot treatments. Therefore, in theory, these two substances could be used together for a more comprehensive approach to skin lightening.
However, it's important to note that both substances have potential side effects. Long-term use of hydroquinone can lead to a condition called ochronosis, which causes the skin to become dark and thick. There are also concerns about the safety of long-term systemic use of glutathione for skin lightening.

Can glutathione and hydroquinone be used together?

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