Is microneedling with PRP safe to perform on active acne?

You can have microneedling/prp with acne. However, I recommend getting a formal consultation with a cosmetic dermatologist to get a treatment plan for active/hormonal acne and skin rejuvenation. In addition to microneedling/prp: lasers, peels, and skin care will help give improvement long term for acne while improving the skin's tone and texture.  Best, Dr. Emer.

Hi @jennygao23! I would recommend avoiding microneedling around active acne to prevent the spread of bacteria. However, if you are doing RF Microneedling like Morpheus 8, you are able to get this procedure done with active acne. Best of luck, Dr. Nima!

I agree you should consider having the active acne treated first.  The microneedling if very likely to make it worse in the short term, which I doubt will make you very happy.  Once the acne is at least somewhat under control you can probably go ahead with microneedling if you still want to.  However, just controlling your acne may make you happy enough that you don't feel like you need microneedling after that.