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The answer is 'usually safe'. Lupus can Koebner, i.e.. any trauma can evoke your body to produce lupus on your skin. If you use a 0.5 mm needle conservatively it is unlikely. For all my lupus patients, I usually perform a test spot, or a very gentle treatment. You should be under the guidance of a Board Certified Physician if you would like skin rejuvenation and have lupus. Video explains how to safely roll. Note- my advice is stick to the .25 mm US rule, or max at ).5 mm if you really want to try. Go slow. Video explains. DR Davin LimLaser and aesthetic dermatologistBrisbane, Australia.