Azzalure / Dysport not working - will the Botox brand work?

Question

Hi. I have become immune to Azzalure - which brand should I try next, Botox and Bocoture are the brands available where I live.

Rupert Critchley, MD, MRCGP · Answer

Hi there it is very uncommon to develop antibody resistance to azzalure. I would try re-treatment after waiting the usual 3-4 months. Sometimes a batch may not be as effective. For those who are, in my experience I would recommend Xeomin which is the same as bocouture. 
Best wishes, 
Dr Rupert

Monika Soni, MD · Answer

Thank you for your question. Dysport, Botox and Xeomin are all botulinum toxin A. The only difference is Xeomin has no extraneous proteins but if one doesn't work it is most likely the technique and not the toxin. Although it is very rare, it is possible to become resistant to a particular brand of neuromodulator after years of treatment. You may respond well to switching brands, such as Botox. I recommend discussing this with your injector. Best of Luck!

Hardik Soni, MD · Answer

Thank you for your question. Although it is very rare, it is possible to become resistant to a particular brand of neuromodulator after years of treatment. You may respond well to switching brands, such as Botox. I recommend discussing this with your injector. Best of Luck!

Rafael Gottenger, MD · Answer

Good Afternoon and thank you for your inquiry. If you developed a Dysport immunity, you have fallen in a very rare category, as is describe to happen in only 1-2% of cases. Be aware that the expertise of the injector and the number of units injected may account. I would recommend you to switch to Botox brand.

Chase Lay, MD · Answer

Thank you for your question.  Some people believe that they are becoming immune to Dysport.  If one brand does not work with you, then you can try Botox or Xeomin if these are available in your area.  You will not know if one brand works better than others until you actually try.

Faiyaaz Kalimullah, MD, FAAD · Answer

Thank you for your question.  Although it is very rare, I have seen a handful of patients who, after years of treatment, have become resistant to a particular brand of neuromodulator.  Some of these patients do respond well to switching brands - it may be worthwhile to discuss trying Botox for your next treatment with your physician.  Best of luck!

Melvin Elson, MD · Answer

Dysport, Botox and Xeomin are all botulinum toxin A. The only difference is Xeomin has no extraneous proteins but if one doesn't work it is most likely the technique and not the toxin. Be sure you see an experienced dermatologist or plastic surgeon

Steven F. Weiner, MD · Answer

It is possible to develop antibodies to Dysport although this is extremely rare in cosmetic cases. The antibody is related to the associated protein and this is different in Botox. So I would try switching and seeing if there is any difference. In my experience, there will probably be only modest differences. Xeomin is free of this associated protein and theoretically an antibody reaction is not possible. You might try this as well.

Azzalure / Dysport not working - will the Botox brand work?

Answers (8)

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