When can I inject more Botox into my calves if 100u each leg wasn't enough? (Photo)

I would recommend waiting at least 2 weeks to see the full effects of your botox treatment before considering additional treatments.  You will likely need less in the second session.

You don't say how long it has been for your injection. Give it at least 2 weeks and then if you still have issues you can certainly be injected again

I rather routinely use botox for calf reduction in my practice. You should not need more than 100 units per leg. The results should easily last you approximately 6 months and I'm sure that in the hands of an experienced injector you will be extremely pleased with your results. Good luck from New York City

The full effect of the injection occurs up to six days from treatment, and most patients return for repeat treatment between 4 and 6 months after the initial injections.  Given the unique nature of your situation, I would recommend consulting with a board-certified physician to explore all the options available to you. Best of luck!