QUICK ANSWER: The longest lasting filler would be silicone or Artefill (PMMA/collagen). Permanent fillers are best avoided due to risk of granulomas, uncorrectable irregularities, and irreversible complications (e.g., vascular injury). LONG ANSWER: Various type of filler materials exist on the market. While these differ based on longevity, there also exists several other characteristics which should be weighed when determining the correct filler for nonsurgical rhinoplasty. In general, the ideal filler for nonsurgical rhinoplasty would be one that is reversible, easy to inject, and provides long-lasting support to the nose. Additionally, many surgeons advocate for non-inflammatory fillers that cause minimal native tissue distortion and thus are easily removed during surgical rhinoplasty. For these reasons, approximately 80% of nonsurgical rhinoplasty performed with HA (e.g., Juvederm, Restylane). Nevertheless, some authors still endorse CaHa as the filler of choice due to its longer duration, improved moldability, and increased stiffness. TAKE HOME POINT: You should consult with a surgeon experienced in both surgical and nonsurgical rhinoplasty so that you receive an unbiased and expert opinion. Hope this helps, Blake Raggio, MD