Hi, i had juvederm injected into my tear troughs over 4 years ago. On one side only, there is persistent redness and a swollen lump. The lump is in the same place that the filler initially lumped when first done. Some days it swells so much my eye doesn't feel fully open. The swelling is soft to touch and causes dark shadows. Water consumption, anount of sleep have no effect. Please help!
February 21, 2017
Answer: Filler causing swelling years later If there is suspicion that there is any degree of persistent filler after a few years I would first attempt to dissolve it, which may take more than one injection, to see if that improves the issue. I would see your injecting physician in order to properly evaluate the area.
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February 21, 2017
Answer: Filler causing swelling years later If there is suspicion that there is any degree of persistent filler after a few years I would first attempt to dissolve it, which may take more than one injection, to see if that improves the issue. I would see your injecting physician in order to properly evaluate the area.
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February 21, 2017
Answer: What is the cause of swelling at site of Juvederm injection 4 years later? In general, HA derivatives like Juvederm are well tolerated & safe. However, there have now been several cases of delayed adverse effects. I did a little research and found the article Foreign Body Reaction to Injectable Hyaluronic Acid: Late Granuloma Formation in the Annals of Dermatology (2015 Apr; 27(2): 224–225. Published online 2015 Mar 24). They propose low grade bacterial infection on a foreign body, such as Juvederm, may result in a delayed granulom formation: "There are several theories regarding the cause of this reaction. First, impurities may lead to hypersensitivity responses. Second, disintegration of the cross-linked product may provoke an inflammatory response. Third, recent studies propose that concomitant bacterial inoculation during the filler injection may cause late granuloma formation. In most cases, bacterial infections become clinically apparent within several days after HA injection. However, biofilms consisting of bacteria, their nutrients, and wastes on the surface of foreign bodies enable persistent minimal infection with little host response, and they become symptomatic months or even years after. Foreign body reactions to biofilm rather than to pathogenic bacteria may produce delayed granuloma formation." Their case is similiar to yours and I recommend you see your family physician or internist. A biopsy of the area will be required for diagnosis.
Helpful 2 people found this helpful
February 21, 2017
Answer: What is the cause of swelling at site of Juvederm injection 4 years later? In general, HA derivatives like Juvederm are well tolerated & safe. However, there have now been several cases of delayed adverse effects. I did a little research and found the article Foreign Body Reaction to Injectable Hyaluronic Acid: Late Granuloma Formation in the Annals of Dermatology (2015 Apr; 27(2): 224–225. Published online 2015 Mar 24). They propose low grade bacterial infection on a foreign body, such as Juvederm, may result in a delayed granulom formation: "There are several theories regarding the cause of this reaction. First, impurities may lead to hypersensitivity responses. Second, disintegration of the cross-linked product may provoke an inflammatory response. Third, recent studies propose that concomitant bacterial inoculation during the filler injection may cause late granuloma formation. In most cases, bacterial infections become clinically apparent within several days after HA injection. However, biofilms consisting of bacteria, their nutrients, and wastes on the surface of foreign bodies enable persistent minimal infection with little host response, and they become symptomatic months or even years after. Foreign body reactions to biofilm rather than to pathogenic bacteria may produce delayed granuloma formation." Their case is similiar to yours and I recommend you see your family physician or internist. A biopsy of the area will be required for diagnosis.
Helpful 2 people found this helpful
