Would Sclerotherapy work for large vein on the hands due to age?

For the hands, I recommend treatment with fillers and/or lasers, which can camouflage the veins. I don't recommend sclerotherapy for this much because people need these veins as they age.

Large varicose veins on the hand are best treated with microphlebectomy. Sclerotherapy would make them shrink but would leave hard, ropy cords which are not acceptable for most patients. As well, they may leave hyperpigmentation along the injected veins. You need to use some adjunctive measures after sclerotherapy to reduce post inflammatory hyperpigmentation. it is those that don't follow such instructions immediately following sclerotherapy, starting on day1 (next day) that seem to get retained hyperpigmentation. I recommend 2 creams: Scleroquin plus and Sclerovase and also Scler-X supplement to reduce post inflammatory hyperpigmentation (see link below) as well as compression stockings for at least 2 weeks.
H Karamanoukian MD FCS
certified vein specialist from ABVLM and double board certified surgeon